Posttranslational modification impact on the mechanism by which amyloid‐β induces synaptic dysfunction
نویسندگان
چکیده
منابع مشابه
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Oligomeric amyloid-β (Aβ) 1-42 disrupts synaptic function at an early stage of Alzheimer's disease (AD). Multiple posttranslational modifications of Aβ have been identified, among which N-terminally truncated forms are the most abundant. It is not clear, however, whether modified species can induce synaptic dysfunction on their own and how altered biochemical properties can contribute to the sy...
متن کاملMechanism for a sliding synaptic modification threshold
Long-term potentiation (LTP) is a long-lasting increase in synaptic effectiveness that results from high frequency stimulation (HFS) of certain excitatory synapses in hippo-campus and neocortex (reviewed by Bliss and Colling-ridge, 1993). Because it is induced by brief episodes of electrical stimulation that resemble patterns observed in the brains of behaving animals, and because it can be ver...
متن کاملPosttranslational modification of MDM2.
The functions of the MDM2 protein, in particular its E3 ubiquitin ligase activity and its ability to interact with a number of cellular proteins intimately involved in growth regulation, are modulated by sumoylation and multisite phosphorylation. These posttranslational mechanisms not only regulate the intrinsic activity of MDM2 in response to cellular stresses, but also govern its subcellular ...
متن کاملthe impact of peer review on efl reviewers writing proficiency
امروزه تصحیح همکلاسی در کلاسهای نگارش یکی از اجزاء لاینفک کلاسهای دانش آموز محور است. تاثیرات مفید تصحیح همکلاسی بر زبان آموزان، معلمان را متقاعد کرده است که علیرغم صرف زمان، انرژی و توان بسیار، از این شیوه ی آموزشی در کلاسهای آموزش نگارش بهره بگیرند. تحقیق حاضر بر آن است تا با مقایسه دو گروه از یادگیرندگان زبان انگلیسی، تاثیر تصحیح همکلاسی را بر توانایی نوشتاری آنها نشان دهد. 122 خانم زبان آمو...
15 صفحه اولthe impact of morphological awareness on the vocabulary development of the iranian efl students
this study investigated the impact of explicit instruction of morphemic analysis and synthesis on the vocabulary development of the students. the participants were 90 junior high school students divided into two experimental groups and one control group. morphological awareness techniques (analysis/synthesis) and conventional techniques were used to teach vocabulary in the experimental groups a...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EMBO reports
سال: 2017
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201643519